Aminopropyltriethoxysilane-mediated surface functionalization of hydroxyapatite nanoparticles: synthesis, characterization, and in vitro toxicity assay | Zendy

Xiangyang Shi | Zendy; Wang | Zendy; Shihui Wen | Zendy; Shen | Zendy; Rui Guo | Zendy; Cao | Zendy

Open Access

Aminopropyltriethoxysilane-mediated surface functionalization of hydroxyapatite nanoparticles: synthesis, characterization, and in vitro toxicity assay

Author(s) -

Xiangyang Shi,

Wang,

Shihui Wen,

Shen,

Rui Guo,

Cao

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s27166

Subject(s) - surface modification , succinic anhydride , zeta potential , nuclear chemistry , transmission electron microscopy , fourier transform infrared spectroscopy , amine gas treating , chemistry , acetic anhydride , nanoparticle , materials science , chemical engineering , polymer chemistry , nanotechnology , organic chemistry , engineering , catalysis

We report on aminopropyltriethoxysilane (APTS)-mediated surface modification of nanohydroxyapatite with different surface functional groups for potential biomedical applications. In this study, nanohydroxyapatite covalently linked with APTS (n-HA-APTS) was reacted with acetic anhydride or succinic anhydride to produce neutralized (n-HA-APTS. Ac) or negatively charged (n-HA-APTS.SAH) nanohydroxyapatite, respectively. Nanohydroxyapatite formed with amine, acetyl, and carboxyl groups was extensively characterized using Fourier transform infrared spectroscopy, transmission electron microscopy, (1)H nuclear magnetic resonance spectroscopy, X-ray diffraction, inductively coupled plasma-atomic emission spectroscopy, and zeta potential measurements.

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