A pH-sensitive multifunctional gene carrier assembled via layer-by-layer technique for efficient gene delivery | Zendy

Na Zhang | Zendy; Li | Zendy; Donghua Liu | Zendy; Miao | Zendy; Liu | Zendy; Sun | Zendy

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A pH-sensitive multifunctional gene carrier assembled via layer-by-layer technique for efficient gene delivery

Author(s) -

Na Zhang,

Li,

Donghua Liu,

Miao,

Liu,

Sun

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26955

Subject(s) - transfection , gene delivery , protamine , cationic liposome , biophysics , cationic polymerization , materials science , in vivo , nuclease , lipofectamine , dna , liposome , chemistry , microbiology and biotechnology , nanotechnology , biochemistry , gene , biology , vector (molecular biology) , polymer chemistry , heparin , recombinant dna

The success of gene therapy asks for the development of multifunctional vectors that could overcome various gene delivery barriers, such as the cell membrane, endosomal membrane, and nuclear membrane. Layer-by-layer technique is an efficient method with easy operation which can be used for the assembly of multifunctional gene carriers. This work describes a pH-sensitive multifunctional gene vector that offered long circulation property but avoided the inhibition of tumor cellular uptake of gene carriers associated with the use of polyethylene glycol.

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