A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis | Zendy

Satya Prakash | Zendy; M. Shao | Zendy; Arghya Paul | Zendy; Sana Abbasi | Zendy; Parminder S. Chahal | Zendy; Jimmy A. Mena | Zendy; Johnny Montes | Zendy; Amine Kamen | Zendy

Open Access

A novel polyethyleneimine-coated adeno-associated virus-like particle formulation for efficient siRNA delivery in breast cancer therapy: preparation and in vitro analysis

Author(s) -

Satya Prakash,

M. Shao,

Arghya Paul,

Sana Abbasi,

Parminder S. Chahal,

Jimmy A. Mena,

Johnny Montes,

Amine Kamen

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26891

Subject(s) - transfection , capsid , gene delivery , small interfering rna , virus like particle , adeno associated virus , genetic enhancement , virus , cytotoxicity , microbiology and biotechnology , western blot , cell , in vitro , mtt assay , cancer cell , cell culture , virology , chemistry , biology , vector (molecular biology) , cancer , gene , recombinant dna , biochemistry , genetics

Systemic delivery of small interfering RNA (siRNA) is limited by its poor stability and limited cell-penetrating properties. To overcome these limitations, we designed an efficient siRNA delivery system using polyethyleneimine-coated virus-like particles derived from adeno-associated virus type 2 (PEI-AAV2-VLPs).

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