In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain | Zendy

Xinhua Tian | Zendy; Tian Tian | Zendy; Tianxiao Wang | Zendy; Peng Wang | Zendy; Xiaoning Lin | Zendy; Jun Wang | Zendy; Dong Wang | Zendy; Lei Ren | Zendy

Open Access

In vitro and in vivo studies on gelatin-siloxane nanoparticles conjugated with SynB peptide to increase drug delivery to the brain

Author(s) -

Xinhua Tian,

Tian Tian,

Tianxiao Wang,

Peng Wang,

Xiaoning Lin,

Jun Wang,

Dong Wang,

Lei Ren

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26541

Subject(s) - peg ratio , in vivo , blood–brain barrier , nanoparticle , drug delivery , biophysics , in vitro , pegylation , biocompatibility , materials science , pharmacology , chemistry , nanotechnology , biochemistry , medicine , biology , microbiology and biotechnology , finance , metallurgy , economics , central nervous system

Nanobiotechnology can provide more efficient tools for diagnosis, targeted and personalized therapy, and increase the chances of brain tumor treatment being successful. Use of nanoparticles is a promising strategy for overcoming the blood-brain barrier and delivering drugs to the brain. Gelatin-siloxane (GS) nanoparticles modified with Tat peptide can enhance plasmid DNA transfection efficiency compared with a commercial reagent.

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