Open AccessTargeting of a platinum-bound sunitinib analog to renal proximal tubular cells
Author(s) -
Robbert J. Kok,
Dolman,
Harmsen,
Pieters,
Sparidans,
Lacombe,
Bálint Szokol,
László Őrfi,
Kéri,
Storm,
Hennink
Publication year - 2012
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s26485
Subject(s) - sunitinib , sunitinib malate , pharmacology , kidney , medicine , lysozyme , conjugate , urology , chemistry , cancer , biochemistry , mathematical analysis , mathematics
Activated proximal tubular cells play an important role in renal fibrosis. We investigated whether sunitinib and a kidney-targeted conjugate of sunitinib were capable of attenuating fibrogenic events in tubulointerstitial fibrosis.
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