Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation | Zendy

Xiao Lin | Zendy; Wang | Zendy; Huang | Zendy; Liang | Zendy; Shen | Zendy; Feng | Zendy; ؉ Ruan | Zendy

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Long-circulating delivery of bioactive polysaccharide from radix ophiopogonis by PEGylation

Author(s) -

Xiao Lin,

Wang,

Huang,

Liang,

Shen,

Feng,

؉ Ruan

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26306

Subject(s) - pegylation , polysaccharide , chemistry , radix (gastropod) , pharmacology , chromatography , biochemistry , medicine , biology , polyethylene glycol , botany

Radix ophiopogonis polysaccharide (ROP) has been found to be effective against myocardial ischemia. One of main problems with its use is its short in-vivo half-life, which makes the development of an effective delivery system necessary. To achieve better therapeutic effects and patient compliance by prolonging its retention in plasma and increasing its distribution in targets, ROP was PEGylated (PEG, polyethylene glycol) in this study.

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