Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery | Zendy

Zhonggui He | Zendy; Lian | Zendy; Sun | Zendy; Yu | Zendy; Liu | Zendy; Wang | Zendy

Open Access

Supramolecular micellar nanoaggregates based on a novel chitosan/vitamin E succinate copolymer for paclitaxel selective delivery

Author(s) -

Zhonggui He,

Lian,

Sun,

Yu,

Liu,

Wang

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26305

Subject(s) - micelle , zeta potential , chitosan , dynamic light scattering , copolymer , differential scanning calorimetry , materials science , drug delivery , solubility , nuclear chemistry , amphiphile , chemical engineering , chemistry , polymer , polymer chemistry , organic chemistry , aqueous solution , nanoparticle , nanotechnology , physics , engineering , thermodynamics

Nowadays, many cytotoxic anticancer drugs exhibit low solubility and poor tumor selectivity, which means that the drug formulation is very important. For example, in the case of paclitaxel (PTX), Cremophor EL(®) (BASF, Ludwigshafen, Germany) needs to be used as a solubilizer in its clinical formulation (Taxol(®), Bristol-Myers Squibb, New York, NY), although it can cause serious side effects. Nanomicellar systems are promising carriers to resolve the above problems, and the polymer chosen is the key element.

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