Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer | Zendy

Jian Huang | Zendy; Ke Wang | Zendy; Liu | Zendy; Zhang | Zendy; Zhu | Zendy; Qiu | Zendy; Wu | Zendy; Fuqiang Hu | Zendy; Wang | Zendy

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Oxaliplatin-incorporated micelles eliminate both cancer stem-like and bulk cell populations in colorectal cancer

Author(s) -

Jian Huang,

Ke Wang,

Liu,

Zhang,

Zhu,

Qiu,

Wu,

Fuqiang Hu,

Wang

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26268

Subject(s) - micelle , oxaliplatin , in vivo , colorectal cancer , drug delivery , cancer cell , cancer research , nanocarriers , cancer , internalization , chemistry , cytotoxicity , in vitro , cell , pharmacology , biophysics , medicine , biology , biochemistry , aqueous solution , organic chemistry , microbiology and biotechnology

The failure of cancer treatments is partly due to the enrichment of cancer stem-like cells (CSLCs) that are resistant to conventional chemotherapy. A novel micelle formulation of oxaliplatin (OXA) encapsulated in chitosan vesicle was developed. The authors postulate that micelle encapsulation of OXA would eliminate both CSLCs and bulk cancer cells in colorectal cancer (CRC).

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