Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis | Zendy

A. Chwalibog | Zendy; Zielinska | Zendy; Ewa Sawosz | Zendy; Marta Grodzik | Zendy; Mateusz Wierzbicki | Zendy; Gromadka | Zendy; Anna Hotowy | Zendy; Sawosz | Zendy; Lozicki | Zendy

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Effect of heparan sulfate and gold nanoparticles on muscle development during embryogenesis

Author(s) -

A. Chwalibog,

Zielinska,

Ewa Sawosz,

Marta Grodzik,

Mateusz Wierzbicki,

Gromadka,

Anna Hotowy,

Sawosz,

Lozicki

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s26070

Subject(s) - myogenesis , in ovo , embryo , myocyte , embryogenesis , biology , heparan sulfate , microbiology and biotechnology , chemistry , medicine , endocrinology , andrology , biochemistry , cell

It was hypothesized that heparan sulfate (HS) as an essential compound for myogenesis and nanoparticles of gold (nano-Au) as highly reactive compounds can affect muscle development as a consequence of molecular regulation of muscle cell formation, and that these effects may be enhanced by a complex of HS conjugated with nano-Au. The objective of the present study was to determine the effect of administration of nano-Au, HS, and a nano-Au+HS complex on the morphological and molecular characteristics of breast muscle during embryogenesis.

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