A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression | Zendy

TongRong Jan | Zendy; Shen | Zendy; Liang | Zendy; ChiaChi Wang | Zendy; Liao | Zendy

Open Access

A role of cellular glutathione in the differential effects of iron oxide nanoparticles on antigen-specific T cell cytokine expression

Author(s) -

TongRong Jan,

Shen,

Liang,

ChiaChi Wang,

Liao

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s25588

Subject(s) - cytokine , splenocyte , glutathione , ovalbumin , reactive oxygen species , iron oxide nanoparticles , interferon gamma , chemistry , immune system , interleukin 2 , antigen , biology , microbiology and biotechnology , immunology , biochemistry , iron oxide , organic chemistry , enzyme

Accumulating evidence indicates that iron oxide nanoparticles modulate immune responses, and induce oxidative stress in macrophages. It was recently reported that iron oxide nanoparticles attenuated antigen-specific immunity in vivo, though the underlying mechanism remains elusive. The present study investigates the direct effect of iron oxide nanoparticles on antigen-specific cytokine expression by T cells, and potential underlying mechanisms.

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