Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages | Zendy

María José Morilla | Zendy; Ana Paula Perez | Zendy; Cosaka | Zendy; Eder Lilia Romero | Zendy

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Uptake and intracellular traffic of siRNA dendriplexes in glioblastoma cells and macrophages

Author(s) -

María José Morilla,

Ana Paula Perez,

Cosaka,

Eder Lilia Romero

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s25235

Subject(s) - small interfering rna , endocytosis , endocytic cycle , gene silencing , microbiology and biotechnology , intracellular , biology , nocodazole , chemistry , cell culture , biochemistry , transfection , cell , cytoskeleton , gene , genetics

Gene silencing using small interfering RNA (siRNA) is a promising new therapeutic approach for glioblastoma. The endocytic uptake and delivery of siRNA to intracellular compartments could be enhanced by complexation with polyamidoamine dendrimers. In the present work, the uptake mechanisms and intracellular traffic of siRNA/generation 7 dendrimer complexes (siRNA dendriplexes) were screened in T98G glioblastoma and J774 macrophages.

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