Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model | Zendy

Dominique ShumTim | Zendy; Arghya Paul | Zendy; Afshan Khan | Zendy; Satya Prakash | Zendy

Open Access

Intramyocardial sustained delivery of placental growth factor using nanoparticles as a vehicle for delivery in the rat infarct model

Author(s) -

Dominique ShumTim,

Arghya Paul,

Afshan Khan,

Satya Prakash

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s25175

Subject(s) - medicine , angiogenesis , placental growth factor , myocardial infarction , proinflammatory cytokine , cardiac function curve , cytokine , in vivo , masson's trichrome stain , cardiology , ischemia , andrology , vascular endothelial growth factor , heart failure , inflammation , immunohistochemistry , biology , microbiology and biotechnology , vegf receptors

Acute myocardial ischemia results in scar formation with ventricular dilatation and eventually heart failure. Placental growth factor (PlGF) is reported to stimulate angiogenesis and improve cardiac function. In this study, it was hypothesized that intramyocardial injection of PlGF contained in nanoparticles can be released at the site of action for an extended time period as a sustained slow-release protective mechanism that accelerates myocardial recovery in a rat model of ischemic cardiomyopathy.

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