Physicochemical properties and biocompatibility of a polymer-paclitaxel conjugate for cancer treatment
Author(s) -
Sang Van,
Yang,
Wang,
Liu,
Xinguo Jiang,
Lei Yu
Publication year - 2011
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s25044
Subject(s) - biocompatibility , paclitaxel , conjugate , materials science , polymer , nanotechnology , cancer therapy , biomedical engineering , cancer , medicine , composite material , mathematical analysis , mathematics , metallurgy
Poly(L-γ-glutamylglutamine) paclitaxel (PGG-PTX) conjugate is a non-diblock polymeric drug nanoparticle intended to improve the therapeutic index of paclitaxel. The purpose of the present study was to elucidate further the physicochemical properties of PGG-PTX in order to proceed with its clinical development.
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