Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting | Zendy

Fulan Xie | Zendy; Nian Yao | Zendy; Yao Qin | Zendy; Qianyu Zhang | Zendy; Huali Chen | Zendy; Mingqing Yuan | Zendy; Jie Tang | Zendy; Xiankun Li | Zendy; Wei Fan | Zendy; Qiang Zhang | Zendy; Yong Wu | Zendy; Hai Li | Zendy; Qin He | Zendy

Open Access

Investigation of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers for brain targeting

Author(s) -

Fulan Xie,

Nian Yao,

Yao Qin,

Qianyu Zhang,

Huali Chen,

Mingqing Yuan,

Jie Tang,

Xiankun Li,

Wei Fan,

Qiang Zhang,

Yong Wu,

Hai Li,

Qin He

Publication year - 2012

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s23771

Subject(s) - liposome , biodistribution , in vivo , dispersity , biophysics , in vitro , drug delivery , chromatography , blood–brain barrier , ex vivo , biomedical engineering , chemistry , materials science , biochemistry , medicine , nanotechnology , biology , organic chemistry , microbiology and biotechnology , endocrinology , central nervous system

An intimidating challenge to transporting drugs into the brain parenchyma is the presence of the blood-brain barrier (BBB). Glucose is an essential nutritional substance for brain function sustenance, which cannot be synthesized by the brain. Its transport primarily depends on the glucose transporters on the brain capillary endothelial cells. In this paper, the brain-targeted properties of glucose-modified liposomes using polyethylene glycols with different chain lengths as the linkers were compared and evaluated to establish an optimized drug-delivery system.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research