Gene therapy for C-26 colon cancer using heparin-polyethyleneimine nanoparticle-mediated survivin T34A
Author(s) -
Xiang Gao,
Zhang,
Gou
Publication year - 2011
Publication title -
international journal of nanomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.245
H-Index - 128
eISSN - 1178-2013
pISSN - 1176-9114
DOI - 10.2147/ijn.s23582
Subject(s) - survivin , in vivo , transfection , in vitro , genetic enhancement , cancer research , apoptosis , cancer , pharmacology , biology , microbiology and biotechnology , medicine , gene , biochemistry
Gene therapy provides a novel method for the prevention and treatment of cancer, but the clinical application of gene therapy is restricted, mainly because of the absence of an efficient and safe gene delivery system. Recently, we developed a novel nonviral gene carrier, ie, heparin-polyethyleneimine (HPEI) nanoparticles for this purpose.
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