Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells | Zendy

Min Han | Zendy; Diao | Zendy; Fu | Zendy; Yulan Hu | Zendy; Jiang Jiang | Zendy; Tsutsumi | Zendy; Wei Nie | Zendy; Chen | Zendy; Jian-Qing Gao | Zendy

Open Access

Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells

Author(s) -

Min Han,

Diao,

Fu,

Yulan Hu,

Jiang Jiang,

Tsutsumi,

Wei Nie,

Chen,

Jian-Qing Gao

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s23099

Subject(s) - doxorubicin , micelle , cytotoxicity , multiple drug resistance , chemistry , drug delivery , materials science , pharmacology , biophysics , chemotherapy , in vitro , biochemistry , medicine , biology , organic chemistry , surgery , aqueous solution , antibiotics

Multidrug resistance remains a major obstacle to successful cancer chemotherapy. Some chemical multidrug resistance inhibitors, such as ciclosporin and verapamil, have been reported to reverse resistance in tumor cells. However, the accompanying side effects have limited their clinical application. In this study, we have developed a novel drug delivery system, ie, a polyethyleneglycol-polycaprolactone (PEG-PCL) copolymer micelle encapsulating doxorubicin, in order to circumvent drug resistance in adriamycin-resistant K562 tumor cells.

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