Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab | Zendy

Ramin Sakhtianchi | Zendy; Fatemeh Atyabi | Zendy; Parisa Yousef | Zendy; Ebrahim VasheghaniFarahani | Zendy; Mousavi Movahedi | Zendy; Rassoul Dinarvand | Zendy

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Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab

Author(s) -

Ramin Sakhtianchi,

Fatemeh Atyabi,

Parisa Yousef,

Ebrahim VasheghaniFarahani,

Mousavi Movahedi,

Rassoul Dinarvand

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s21523

Subject(s) - dynamic light scattering , doxorubicin , chitosan , isothermal titration calorimetry , nanoparticle , conjugate , chemistry , drug delivery , drug carrier , zeta potential , targeted drug delivery , differential scanning calorimetry , materials science , nuclear chemistry , organic chemistry , nanotechnology , biochemistry , medicine , thermodynamics , mathematical analysis , surgery , mathematics , physics , chemotherapy

Targeting drugs to their sites of action to overcome the systemic side effects associated with most antineoplastic agents is still a major challenge in pharmaceutical research. In this study, the monoclonal antibody, trastuzumab, was used as a targeting agent in nanoparticles carrying the antitumor drug, doxorubicin, specifically to its site of action.

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