Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition | Zendy

Haroon Rahim | Zendy; Abdul Sadiq | Zendy; Shahzeb Khan | Zendy; Fazli Amin | Zendy; Riaz Ullah | Zendy; Abdelaaty A. Shahat | Zendy; Hafiz Majid Mahmood | Zendy

Open Access

<p>Fabrication and characterization of glimepiride nanosuspension by ultrasonication-assisted precipitation for improvement of oral bioavailability and in vitro α-glucosidase inhibition</p>

Author(s) -

Haroon Rahim,

Abdul Sadiq,

Shahzeb Khan,

Fazli Amin,

Riaz Ullah,

Abdelaaty A. Shahat,

Hafiz Majid Mahmood

Publication year - 2019

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s210548

Subject(s) - bioavailability , sonication , differential scanning calorimetry , chromatography , materials science , dispersity , solubility , particle size , dissolution , nuclear chemistry , chemistry , pharmacology , medicine , organic chemistry , physics , polymer chemistry , thermodynamics

We aimed to enhance the solubility, dissolution rate, oral bioavailability, and α-glucosidase inhibition of glimepiride (Glm) by fabricating its nanosuspension using a precipitation-ultrasonication approach.

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