A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice | Zendy

TongRong Jan | Zendy; Shen | Zendy; ChiaChi Wang | Zendy; Liao | Zendy

Open Access

A single exposure to iron oxide nanoparticles attenuates antigen-specific antibody production and T-cell reactivity in ovalbumin-sensitized BALB/c mice

Author(s) -

TongRong Jan,

Shen,

ChiaChi Wang,

Liao

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s21019

Subject(s) - ovalbumin , splenocyte , iron oxide nanoparticles , immune system , antigen , viability assay , sensitization , antibody , balb/c , chemistry , immunology , medicine , iron oxide , biochemistry , cell , organic chemistry

Superparamagnetic iron oxide nanoparticles have been used in clinical applications as a diagnostic contrasting agent. Previous studies showed that iron oxide nanoparticles deposited in the liver and spleen after systemic administration. The present study investigated the effect of iron oxide nanoparticles on antigen-specific immune responses in mice sensitized with the T cell-dependent antigen ovalbumin (OVA).

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