Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin | Zendy

Cui | Zendy; Amit Kumar | Zendy; Xinran Li | Zendy; Michael A. Sandoval | Zendy; Leticia B Rodriguez | Zendy; Brian R. Sloat | Zendy

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Permeation of antigen protein-conjugated nanoparticles and live bacteria through microneedle-treated mouse skin

Author(s) -

Cui,

Amit Kumar,

Xinran Li,

Michael A. Sandoval,

Leticia B Rodriguez,

Brian R. Sloat

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s20413

Subject(s) - ovalbumin , permeation , in vivo , immune system , transdermal , nanoparticle , immunization , materials science , chemistry , medicine , immunology , pharmacology , nanotechnology , biology , biochemistry , microbiology and biotechnology , membrane

The present study was designed to evaluate the extent to which pretreatment with microneedles can enhance skin permeation of nanoparticles in vitro and in vivo. Permeation of live bacteria, which are physically nanoparticles or microparticles, through mouse skin pretreated with microneedles was also studied to evaluate the potential risk of microbial infection.

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