Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models | Zendy

Kalaimathi Murugesan | Zendy; Jinsha Koroth | Zendy; P. Srinivasan | Zendy; Amrita Singh | Zendy; Sanjana Mukundan | Zendy; Subhas S. Karki | Zendy; Bibha Choudhary | Zendy; Chhitar M. Gupta | Zendy

Open Access

<p>Effects of green synthesised silver nanoparticles (ST06-AgNPs) using curcumin derivative (ST06) on human cervical cancer cells (HeLa) in vitro and EAC tumor bearing mice models</p>

Author(s) -

Kalaimathi Murugesan,

Jinsha Koroth,

P. Srinivasan,

Amrita Singh,

Sanjana Mukundan,

Subhas S. Karki,

Bibha Choudhary,

Chhitar M. Gupta

Publication year - 2019

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s202404

Subject(s) - silver nanoparticle , hela , nuclear chemistry , curcumin , nanoparticle , dynamic light scattering , fourier transform infrared spectroscopy , zeta potential , mtt assay , surface plasmon resonance , materials science , cytotoxicity , chemistry , nanotechnology , in vitro , chemical engineering , biochemistry , engineering

In recent years, green synthesized silver nanoparticles have been increasingly investigated for their anti-cancer potential. In the present study, we aimed at the biosynthesis of silver nanoparticles (AgNPs) using a curcumin derivative, ST06. Although, the individual efficacies of silver nanoparticles or curcumin derivatives have been studied previously, the synergistic cytotoxic effects of curcumin derivative and silver nanoparticles in a single nanoparticulate formulation have not been studied earlier specifically on animal models. This makes this study novel compared to the earlier synthesized curcumin derivative or silver nanoparticles studies. The aim of the study was to synthesize ST06 coated silver nanoparticles (ST06-AgNPs) using ST06 as both reducing and coating agent.

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