Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells | Zendy

Amoura Abou-El-Naga | Zendy; Ghada Mutawa | Zendy; Ibrahim M. ElSherbiny | Zendy; Shaker A. Mousa | Zendy

Open Access

Activation of polymeric nanoparticle intracellular targeting overcomes chemodrug resistance in human primary patient breast cancer cells

Author(s) -

Amoura Abou-El-Naga,

Ghada Mutawa,

Ibrahim M. ElSherbiny,

Shaker A. Mousa

Publication year - 2018

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s182184

Subject(s) - intracellular , materials science , nanoparticle , cancer , breast cancer , cancer cell , human breast , cancer research , nanotechnology , medicine , microbiology and biotechnology , biology

Successfully overcoming obstacles due to anticancer drugs' toxicity and achieving effective treatment using unique nanotechnology is challenging. The complex nature of breast tumors is mainly due to chemoresistance. Successful docetaxel (DTX) delivery by nanoparticles (NPs) through inhibition of multidrug resistance (MDR) can be a bridge to enhance intracellular dose and achieve higher cytotoxicity for cancer cells.

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