Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells | Zendy

Weikai Zhang | Zendy; Ilmari Pyykkö | Zendy; Jing Zou | Zendy; Ya Zhang | Zendy; Marian Loebler | Zendy; Klaus-Peter Schmitz | Zendy

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Nuclear entry of hyperbranched polylysine nanoparticles into cochlear cells

Author(s) -

Weikai Zhang,

Ilmari Pyykkö,

Jing Zou,

Ya Zhang,

Marian Loebler,

Klaus-Peter Schmitz

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s16973

Subject(s) - spiral ganglion , organ of corti , cochlea , round window , modiolus (cochlea) , lipofectamine , in vivo , gene delivery , microbiology and biotechnology , cochlear nucleus , transfection , cell culture , biology , pathology , chemistry , anatomy , medicine , biochemistry , nucleus , gene , genetics , vector (molecular biology) , recombinant dna

Gene therapy is a potentially effective therapeutic modality for treating sensorineural hearing loss. Nonviral gene delivery vectors are expected to become extremely safe and convenient, and nanoparticles are the most promising types of vectors. However, infrequent nuclear localization in the cochlear cells limits their application for gene therapy. This study aimed to investigate the potential nuclear entry of hyperbranched polylysine nanoparticles (HPNPs) for gene delivery to cochlear targets.

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