Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study | Zendy

Ghullam Reza Barbari | Zendy; Farid Abedin Dorkoosh | Zendy; Mohsen Amini | Zendy; Nika Bahari Javan | Zendy; Mohammad Sharifzadeh | Zendy; Fatemeh Atyabi | Zendy; Saeed Balalaie | Zendy; Niyousha Rafiee Tehrani | Zendy; Morteza Rafiee Tehrani | Zendy

Open Access

Synthesis and characterization of a novel peptide-grafted Cs and evaluation of its nanoparticles for the oral delivery of insulin, in vitro, and in vivo study

Author(s) -

Ghullam Reza Barbari,

Farid Abedin Dorkoosh,

Mohsen Amini,

Nika Bahari Javan,

Mohammad Sharifzadeh,

Fatemeh Atyabi,

Saeed Balalaie,

Niyousha Rafiee Tehrani,

Morteza Rafiee Tehrani

Publication year - 2018

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s161240

Subject(s) - chitosan , insulin , in vivo , nanoparticle , drug delivery , peptide , chemistry , drug carrier , in vitro , pharmacology , biophysics , materials science , biochemistry , nanotechnology , medicine , organic chemistry , microbiology and biotechnology , biology

Despite years of experience and rigorous research, injectable insulin is the sole trusted treatment method to control the blood glucose level in diabetes type 1 patients, but injection of insulin is painful and poses a lot of stress to the patients, especially children, therefore, development of a non-injectable formulation of insulin is a major breakthrough in the history of medicine and pharmaceutical sciences.

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