Effect of selected drugs used in asthma treatment on morphology and elastic properties of red blood cells | Zendy

Zuk | Zendy; Marta TargoszKorecka | Zendy; Szymonski | Zendy

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Effect of selected drugs used in asthma treatment on morphology and elastic properties of red blood cells

Author(s) -

Zuk,

Marta TargoszKorecka,

Szymonski

Publication year - 2011

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s15802

Subject(s) - materials science , morphology (biology) , asthma , pharmacology , medicine , immunology , biology , genetics

The main function of red blood cells is to transport oxygen to all parts of the body with the help of hemoglobin. Other proteins of the cell membrane can attach xenobiotics (eg, drugs) from the blood and transport them throughout the body. Only drugs able to bind to the membrane of the red blood cell can modify its structure and elastic properties. The morphology and local elastic properties of living red blood cells incubated with drug solutions commonly used in the treatment of severe asthma were studied by atomic force microscopy and nanoindentation with an atomic force microscopy tip.

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