Selective axonal growth of embryonic hippocampal neurons according to topographic features of various sizes and shapes | Zendy

David Y. Fozdar | Zendy; S Chen | Zendy; Christine E. Schmidt | Zendy

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Selective axonal growth of embryonic hippocampal neurons according to topographic features of various sizes and shapes

Author(s) -

David Y. Fozdar,

S Chen,

Christine E. Schmidt

Publication year - 2010

Publication title -

international journal of nanomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.245

H-Index - 128

eISSN - 1178-2013

pISSN - 1176-9114

DOI - 10.2147/ijn.s12376

Subject(s) - axon , hippocampal formation , neuroscience , embryonic stem cell , microscale chemistry , axon guidance , biology , anatomy , psychology , biochemistry , gene , mathematics education

Understanding how surface features influence the establishment and outgrowth of the axon of developing neurons at the single cell level may aid in designing implantable scaffolds for the regeneration of damaged nerves. Past studies have shown that micropatterned ridge-groove structures not only instigate axon polarization, alignment, and extension, but are also preferred over smooth surfaces and even neurotrophic ligands.

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