Progressive multifocal leukoencephalopathy developing in a fludarabine naïve patient with chronic lymphocytic leukemia | Zendy

Melissa Ooi | Zendy

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Progressive multifocal leukoencephalopathy developing in a fludarabine naïve patient with chronic lymphocytic leukemia

Author(s) -

Melissa Ooi

Publication year - 2009

Publication title -

international journal of general medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.722

H-Index - 36

ISSN - 1178-7074

DOI - 10.2147/ijgm.s4380

Subject(s) - medicine , fludarabine , chronic lymphocytic leukemia , progressive multifocal leukoencephalopathy , leukoencephalopathy , leukemia , pediatrics , pathology , chemotherapy , immunology , disease , cyclophosphamide , multiple sclerosis

We report a case of progressive multifocal leukoencephalopathy developing in a fludarabine-naïve patient with chronic lymphocytic leukemia. We suggest that progressive multifocal leukoencephalopathy should be considered in any chronic lymphocytic leukemia patient with unexplained neurological symptoms. Treatment history does not necessarily require fludarabine. Intrathecal cytosine arabinoside although unsuccessful in this patient, is a therapeutic option to consider in patients experiencing side effects from systemic therapy.

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