Clarithromycin-induced rhabdomyolysis: a case report | Zendy

Fabio Monzani | Zendy; Pasqualetti | Zendy; Bini | Zendy; Tognigni | Zendy; Polini | Zendy

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Clarithromycin-induced rhabdomyolysis: a case report

Author(s) -

Fabio Monzani,

Pasqualetti,

Bini,

Tognigni,

Polini

Publication year - 2012

Publication title -

international journal of general medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.722

H-Index - 36

ISSN - 1178-7074

DOI - 10.2147/ijgm.s29845

Subject(s) - rhabdomyolysis , clarithromycin , medicine , etiology , statin , pharmacology , helicobacter pylori

Rhabdomyolysis is a clinical and laboratory syndrome that is caused by various etiologies, involving the skeletal muscle. Clarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis related to macrolide-statin interaction has previously been described. To date, rhabdomyolysis induced by clarithromycin has been described in only one previous report. We describe the case of a 90-year-old Caucasian male, admitted to the University Hospital of Pisa for dyspnea, who developed rhabdomyolysis associated with clarithromycin administration.

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