Adjusting wheal size measures to correct atopy misclassification | Zendy

Hongmei Zhang | Zendy; Wilfried Karmaus | Zendy; Jianjun Gan | Zendy; Weichao Bao | Zendy; Yan D. Zhao | Zendy; Dewi Rahardja | Zendy; John W. Holloway | Zendy; Martha Scott | Zendy; Syed Hasan Arshad | Zendy

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Adjusting wheal size measures to correct atopy misclassification

Author(s) -

Hongmei Zhang,

Wilfried Karmaus,

Jianjun Gan,

Weichao Bao,

Yan D. Zhao,

Dewi Rahardja,

John W. Holloway,

Martha Scott,

Syed Hasan Arshad

Publication year - 2011

Publication title -

international journal of general medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.722

H-Index - 36

ISSN - 1178-7074

DOI - 10.2147/ijgm.s22193

Subject(s) - medicine , atopy , cutoff , house dust mite , population , asthma , allergy , sample size determination , dermatology , immunology , allergen , statistics , mathematics , physics , environmental health , quantum mechanics

Skin prick testing (SPT) is fundamental to the practice of clinical allergy identifying relevant allergens and predicting the clinical expression of disease. Wheal sizes on SPT are used to identify atopic cases, and the cut-off value for a positive test is commonly set at 3 mm. However, the measured wheal sizes do not solely reflect the magnitude of skin reaction to allergens, but also skin reactivity (reflected in the size of histamine reaction) and other random or non-random factors. We sought to estimate wheal sizes exclusively due to skin response to allergens and propose gender-specific cutoff points of atopy.

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