Pleiotropic effects of the HMG-CoA reductase inhibitors | Zendy

Orlando Santana | Zendy; Christos G. Mihos | Zendy

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Pleiotropic effects of the HMG-CoA reductase inhibitors

Author(s) -

Orlando Santana,

Christos G. Mihos

Publication year - 2011

Publication title -

international journal of general medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.722

H-Index - 36

ISSN - 1178-7074

DOI - 10.2147/ijgm.s16779

Subject(s) - hmg coa reductase , pleiotropy , medicine , reductase , hyperlipidemia , pharmacology , bioinformatics , enzyme , biochemistry , endocrinology , biology , gene , phenotype , diabetes mellitus

The HMG-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes. These secondary actions are known as pleiotropic effects. Our paper serves as a focused and updated discussion on the pleiotropy of statins and emphasizes the importance of randomized placebo-controlled trials to further elucidate this interesting phenomenon.

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