Novel drugs in the management of difficult-to-treat hepatitis C genotypes
Author(s) -
Lesley Miller,
Judith E. Cartwright
Publication year - 2013
Publication title -
hepatic medicine evidence and research
Language(s) - English
Resource type - Journals
ISSN - 1179-1535
DOI - 10.2147/hmer.s48545
Subject(s) - ribavirin , medicine , pegylated interferon , hepatitis c virus , ns5a , adverse effect , hepatitis c , telaprevir , ns5b , sofosbuvir , combination therapy , immunology , virology , hepacivirus , virus
Hepatitis C virus (HCV) infection is the most common chronic bloodborne infection in the United States, with approximately 3.2 million Americans being chronically infected. Rates of HCV-related end-stage liver disease and its associated morbidity and mortality have yet to peak, so there is a pressing need for more effective and tolerable HCV treatment. HCV genotypes 1, 4, 5, and 6 are considered difficult to treat, and the need for improved therapies is especially great for persons infected with these genotypes.
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