The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-&beta;1-induced cellular damage | Zendy

Andreas K. Nüssler | Zendy; Ehnert | Zendy; Bachmann | Zendy; Martinez Sanchez | Zendy; Georg Damm | Zendy; Pscherer | Zendy; Stöckle | Zendy; Dooley | Zendy; Lukoschek | Zendy; Nuessler | Zendy; Sebastian Mueller | Zendy

Open Access

The right choice of antihypertensives protects primary human hepatocytes from ethanol- and recombinant human TGF-β1-induced cellular damage

Author(s) -

Andreas K. Nüssler,

Ehnert,

Bachmann,

Martinez Sanchez,

Georg Damm,

Pscherer,

Stöckle,

Dooley,

Lukoschek,

Nuessler,

Sebastian Mueller

Publication year - 2013

Publication title -

hepatic medicine evidence and research

Language(s) - English

Resource type - Journals

ISSN - 1179-1535

DOI - 10.2147/hmer.s38754

Subject(s) - recombinant dna , ethanol , chemistry , pharmacology , beta (programming language) , microbiology and biotechnology , biochemistry , medicine , biology , gene , computer science , programming language

Patients with alcoholic liver disease (ALD) often suffer from high blood pressure and rely on antihypertensive treatment. Certain antihypertensives may influence progression of chronic liver disease. Therefore, the aim of this study is to investigate the impact of the commonly used antihypertensives amlodipine, captopril, furosemide, metoprolol, propranolol, and spironolactone on alcohol-induced damage toward human hepatocytes (hHeps).

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