New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem | Zendy

Kristi L. Neufeld | Zendy; Maged Zeineldin | Zendy

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New insights from animal models of colon cancer: inflammation control as a new facet on the tumor suppressor APC gem

Author(s) -

Kristi L. Neufeld,

Maged Zeineldin

Publication year - 2015

Publication title -

gastrointestinal cancer targets and therapy

Language(s) - English

Resource type - Journals

ISSN - 1179-9919

DOI - 10.2147/gictt.s51386

Subject(s) - colorectal cancer , inflammatory bowel disease , suppressor , adenomatous polyposis coli , carcinogenesis , mouse model of colorectal and intestinal cancer , medicine , colitis , disease , cancer , familial adenomatous polyposis , cancer research , inflammation , immunology

Colorectal cancer (CRC) is one of the most common causes of cancer-related deaths worldwide. As with other cancers, CRC is a genetic disease, however, several risk factors including diet and chronic colitis predispose to the disease. Mutations in the tumor suppressor adenomatous polyposis coli (APC) initiate most cases of CRC. Recent data from mouse models suggest that APC mutations and colitis are not completely independent factors in colorectal carcinogenesis. Here, we review the evidence supporting an interaction between APC muta- tions and chronic colitis. We will also discuss possible pathophysiologic mechanisms behind this interaction.

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