Open AccessSynergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity
Author(s) -
Michael B. Zemel,
Bruckbauer
Publication year - 2013
Publication title -
diabetes metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s40840
Subject(s) - metformin , resveratrol , endocrinology , medicine , insulin , insulin resistance , type 2 diabetes , protein kinase a , chemistry , pharmacology , diabetes mellitus , kinase , biochemistry
The purpose of this study was to determine whether a mixture of the polyphenol, resveratrol, and the leucine metabolite, hydroxymethylbutyrate (HMB), acts synergistically with low doses of metformin to impact insulin sensitivity and AMP-activated protein kinase-dependent outcomes in cell culture and in diabetic mice.
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