Managing diabetic patients with moderate or severe renal impairment using DPP-4 inhibitors: focus on vildagliptin
Author(s) -
G Penno,
Russo Russo,
Stefano Del Prato
Publication year - 2013
Publication title -
diabetes metabolic syndrome and obesity
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.853
H-Index - 43
ISSN - 1178-7007
DOI - 10.2147/dmso.s28951
Subject(s) - vildagliptin , medicine , linagliptin , glycemic , tolerability , hypoglycemia , renal function , diabetes mellitus , dipeptidyl peptidase 4 , glycated hemoglobin , type 2 diabetes , dipeptidyl peptidase 4 inhibitor , kidney disease , urology , endocrinology , adverse effect
Dipeptidyl peptidase-4 (DPP-4) inhibitors are novel classified oral anti-diabetic drugs for the treatment of type 2 diabetes mellitus (T2DM) that provide important reduction in glycated hemoglobin, with a low risk for hypoglycemia and no weight gain. In T2DM patients with reduced renal function, adequate glycemic control is essential to delay the progress of kidney dysfunction, but they are at a greater risk of experiencing hypoglycemic events, especially with longer-acting sulfonylureas and meglitinides.
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