Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity | Zendy

Rolf P. Kreutz | Zendy; Alloosh | Zendy; Mansour | Zendy; Kreutz | Zendy; Zach Neeb | Zendy; Flockhart | Zendy; Michael Sturek | Zendy

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Morbid obesity and metabolic syndrome in Ossabaw miniature swine are associated with increased platelet reactivity

Author(s) -

Rolf P. Kreutz,

Alloosh,

Mansour,

Kreutz,

Zach Neeb,

Flockhart,

Michael Sturek

Publication year - 2011

Publication title -

diabetes metabolic syndrome and obesity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.853

H-Index - 43

ISSN - 1178-7007

DOI - 10.2147/dmso.s17105

Subject(s) - platelet , obesity , medicine , morbid obesity , metabolic syndrome , cardiology , reactivity (psychology) , pathology , weight loss , alternative medicine

Metabolic syndrome (MetS) and type 2 diabetes mellitus in humans are associated with increased platelet activation and hyperreactivity of platelets to various agonists. Ossabaw swine develop all the hallmarks of MetS including obesity, insulin resistance, hypertension, dyslipidemia, endothelial dysfunction, and coronary artery disease when being fed excess calorie atherogenic diet. We hypothesized that Ossabaw swine with MetS would exhibit increased platelet reactivity compared with lean pigs without MetS.

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