Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine | Zendy

Donald J. Kellerman | Zendy; Pamela S. Douglas | Zendy; Shashidhar Kori | Zendy; Mangum | Zendy; SheinChung Chow | Zendy; Robert J. Noveck | Zendy

Open Access

Assessing acute systemic effects of an inhaled drug with serial echocardiography: a placebo-controlled comparison of inhaled and intravenous dihydroergotamine

Author(s) -

Donald J. Kellerman,

Pamela S. Douglas,

Shashidhar Kori,

Mangum,

SheinChung Chow,

Robert J. Noveck

Publication year - 2013

Publication title -

drug design development and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 64

ISSN - 1177-8881

DOI - 10.2147/dddt.s44093

Subject(s) - medicine , placebo , dihydroergotamine , anesthesia , crossover study , adverse effect , area under the curve , blood pressure , pharmacokinetics , cardiology , alternative medicine , pathology , migraine

MAP0004 is an investigational product which delivers dihydroergotamine (DHE) through the lung via a breath-synchronized metered dose inhaler. The objective of this study was to compare the acute effects of orally inhaled and intravenous (IV) DHE to placebo on maximum change and area under the curve for pulmonary arterial systolic pressure (PASP).

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