Advances with RNA interference in Alzheimer&rsquo;s disease research | Zendy

Weien Yuan | Zendy; Shun Chen | Zendy; Xuemei Ge | Zendy; Yinghui Chen | Zendy; Nan Lu | Zendy; Zhenguo Liu | Zendy

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Advances with RNA interference in Alzheimer’s disease research

Author(s) -

Weien Yuan,

Shun Chen,

Xuemei Ge,

Yinghui Chen,

Nan Lu,

Zhenguo Liu

Publication year - 2013

Publication title -

drug design development and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 64

ISSN - 1177-8881

DOI - 10.2147/dddt.s40229

Subject(s) - rna interference , disease , gene , rna , biology , bioinformatics , computational biology , medicine , neuroscience , genetics , pathology

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized clinically by memory and cognitive dysfunction. Unfortunately, there is no effective therapeutic method for AD treatment or ways to halt disease progression. Many mechanisms are involved in the disease, including genes mutation and protein dysfunction. RNA interference (RNAi) technology may potentially be able to control AD. It can inhibit the protein expression of specific genes by activating a sequence-specific RNA degradation process. This is a powerful tool with which to study gene function, investigate the mechanism of the disease, and validate drug targets. In this review, we highlight the advances in RNAi technology in the investigation and treatment of AD.

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