Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa &beta;-related pathway in rats | Zendy

Guanglei Fu | Zendy; Hua Wang | Zendy; Youli Cai | Zendy; Hui Zhao | Zendy; Wenjun Fu | Zendy

Open Access

Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa β-related pathway in rats

Author(s) -

Guanglei Fu,

Hua Wang,

Youli Cai,

Hui Zhao,

Wenjun Fu

Publication year - 2018

Publication title -

drug design development and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 64

ISSN - 1177-8881

DOI - 10.2147/dddt.s164324

Subject(s) - tunel assay , pharmacology , proinflammatory cytokine , nissl body , apoptosis , intracerebral hemorrhage , medicine , western blot , inflammation , chemistry , immunology , pathology , biochemistry , staining , gene , subarachnoid hemorrhage

Intracerebral hemorrhage (ICH) is one of the most common acute cerebrovascular diseases with high mortality. Numerous studies have shown that inflammatory response played an important role in ICH-induced brain injury. Theaflavin (TF) extracted from black tea has various biological functions including anti-inflammatory activity. In this study, we investigated whether TF could inhibit ICH-induced inflammatory response in rats and explored its mechanism.

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