Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity | Zendy

Muhammad Umar Khayam Sahibzada | Zendy; Abdul Sadiq | Zendy; Hani Faidah | Zendy; Muhammad Khurram | Zendy; Muhammad Usman Amin | Zendy; Abdul Haseeb | Zendy; Maria Kakar | Zendy

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Berberine nanoparticles with enhanced in vitro bioavailability: characterization and antimicrobial activity

Author(s) -

Muhammad Umar Khayam Sahibzada,

Abdul Sadiq,

Hani Faidah,

Muhammad Khurram,

Muhammad Usman Amin,

Abdul Haseeb,

Maria Kakar

Publication year - 2018

Publication title -

drug design development and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 64

ISSN - 1177-8881

DOI - 10.2147/dddt.s156123

Subject(s) - berberine , bioavailability , dissolution , solubility , chemistry , precipitation , nuclear chemistry , antibacterial activity , chromatography , differential scanning calorimetry , pharmacology , bacteria , organic chemistry , medicine , physics , meteorology , thermodynamics , biology , genetics

Berberine is an isoquinoline alkaloid widely used in Ayurveda and traditional Chinese medicine to treat illnesses such as hypertension and inflammatory conditions, and as an anticancer and hepato-protective agent. Berberine has low oral bioavailability due to poor aqueous solubility and insufficient dissolution rate, which can reduce the efficacy of drugs taken orally. In this study, evaporative precipitation of nanosuspension (EPN) and anti-solvent precipitation with a syringe pump (APSP) were used to address the problems of solubility, dissolution rate and bioavailability of berberine.

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