Comparative bioequivalence studies of tramadol hydrochloride sustained-release 200 mg tablets
Author(s) -
Khandave Suhas,
Satish V Sawant,
Santosh Joshi,
Yatish Bansal,
Sonal Sushil Kadam
Publication year - 2010
Publication title -
drug design development and therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.964
H-Index - 64
ISSN - 1177-8881
DOI - 10.2147/dddt.s15133
Subject(s) - bioequivalence , tramadol , pharmacokinetics , crossover study , tramadol hydrochloride , medicine , pharmacology , bioavailability , metabolite , half life , dosing , cyp2d6 , confidence interval , analgesic , chromatography , chemistry , alternative medicine , pathology , cytochrome p450 , metabolism , placebo
Tramadol hydrochloride is available as 50 mg immediate-release (IR) and 100 mg, 200 mg, and 300 mg sustained-release (SR) tablets. The recommended dose of tramadol is 50-100 mg IR tablets every 4-6 hours. The tramadol SR 200 mg tablet is a better therapeutic option, with a reduced frequency of dosing, and improved patient compliance and quality of life. The present study evaluated the bioequivalence of a generic tramadol SR 200 mg tablet.
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