4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5 | Zendy

Jing Ju | Zendy; Nan Wang | Zendy; Jiali Wang | Zendy; FanRong Wu | Zendy; JinFang Ge | Zendy; Feihu Chen | Zendy

Open Access

4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5

Author(s) -

Jing Ju,

Nan Wang,

Jiali Wang,

FanRong Wu,

JinFang Ge,

Feihu Chen

Publication year - 2018

Publication title -

drug design development and therapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.964

H-Index - 64

ISSN - 1177-8881

DOI - 10.2147/dddt.s151029

Subject(s) - downregulation and upregulation , cell growth , chemistry , cancer cell , cell culture , cell migration , mtt assay , cancer research , microbiology and biotechnology , cancer , cell , biology , medicine , biochemistry , genetics , gene

4-Amino-2-trifluoromethyl-phenyl retinate (ATPR), a novel retinoid derivative, inhibits proliferation and induces differentiation in many cancer cells. In this study, the inhibitory effects of ATPR on the proliferation, invasion, and migration of breast cancer (BC) cells, and the relationship between ATPR and the expression of the intracellular lipid-binding proteins CRABP2 and FABP5 were investigated.

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