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Management of antipsychotic treatment discontinuation and interruptions using model-based simulations
Author(s) -
Cynthia Samtani,
John J. Sheehan,
Fu,
Remmerie,
Sliwa,
Alphs
Publication year - 2012
Publication title -
clinical pharmacology advances and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 27
ISSN - 1179-1438
DOI - 10.2147/cpaa.s32735
Subject(s) - paliperidone , risperidone , discontinuation , paliperidone palmitate , pharmacokinetics , antipsychotic , medicine , pharmacology , atypical antipsychotic , schizophrenia (object oriented programming) , oral administration , plasma concentration , psychology , psychiatry
Medication nonadherence is a well described and prevalent clinical occurrence in schizophrenia. These pharmacokinetic model-based simulations analyze predicted antipsychotic plasma concentrations in nonadherence and treatment interruption scenarios and with treatment reinitiation.

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