Open AccessIn vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds
Author(s) -
Hamilton
Publication year - 2010
Publication title -
clinical pharmacology advances and applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.685
H-Index - 27
ISSN - 1179-1438
DOI - 10.2147/cpaa.s11795
Subject(s) - cytotoxicity , in vitro , platinum , chemistry , platinum compounds , pharmacology , combinatorial chemistry , biochemistry , biology , catalysis
Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a panel of permanent cell lines, including small cell lung cancer (SCLC), ovarian cancer, and Ewing's sarcoma in vitro.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom