C-reactive protein correlates with tissue oxygen availability in patients with stable COPD | Zendy

S. Baldi | Zendy; Gian Domenico Pinna | Zendy; Piera Mombaruzzo | Zendy; Milena Biglieri | Zendy; Angelo De Martini | Zendy; Paolo Palange | Zendy

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C-reactive protein correlates with tissue oxygen availability in patients with stable COPD

Author(s) -

S. Baldi,

Gian Domenico Pinna,

Piera Mombaruzzo,

Milena Biglieri,

Angelo De Martini,

Paolo Palange

Publication year - 2008

Publication title -

international journal of copd

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.394

H-Index - 67

eISSN - 1178-2005

pISSN - 1176-9106

DOI - 10.2147/copd.s3819

Subject(s) - copd , oxygen , hemoglobin , medicine , c reactive protein , oxygen tension , systemic inflammation , arterial blood , reactive oxygen species , cardiology , inflammation , gastroenterology , chemistry , biochemistry , organic chemistry

Arterial oxygen tension, oxygen delivery to tissue, and systemic inflammation are recognized as pivotal factors in the progression of chronic obstructive pulmonary disease (COPD). However, interconnections between systemic inflammation and tissue oxygen availability are scantly investigated. Tissue oxygen availability depends on arterial PaO2, oxygen concentration, hemoglobin oxygen affinity (P50), and hemoglobin oxygen binding capacity (ceHb). As the integrated changes of those indices are summarized by oxygen extraction tension (PaO2x), the objective of this study was to explore the association between C-reactive protein (CRP) blood levels and either PaO2x or each of its determinants, in stable COPD.

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