Open AccessEffect of COPD treatments on MRP1-mediated transport in bronchial epithelial cells
Author(s) -
Dirkje S. Postma
Publication year - 2008
Publication title -
international journal of copd
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.394
H-Index - 67
eISSN - 1178-2005
pISSN - 1176-9106
DOI - 10.2147/copd.s2817
Subject(s) - formoterol , budesonide , copd , ipratropium bromide , medicine , pharmacology , ipratropium , chemistry , bronchodilator , asthma
Smoking is the principle risk factor for development of chronic obstructive pulmonary disease (COPD). Multidrug resistance-associated protein 1 (MRP1) is known to protect against toxic compounds and oxidative stress, and might play a role in protection against smoke-induced disease progression. We questioned whether MRP1-mediated transport is influenced by pulmonary drugs that are commonly prescribed in COPD.
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