Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis | Zendy

Xiao Liang | Zendy; Chang Xu | Zendy; Xiaocheng Cao | Zendy; Wanchun Wang | Zendy

Open Access

<p>Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis</p>

Author(s) -

Xiao Liang,

Chang Xu,

Xiaocheng Cao,

Wanchun Wang

Publication year - 2019

Publication title -

cancer management and research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.024

H-Index - 40

ISSN - 1179-1322

DOI - 10.2147/cmar.s222708

Subject(s) - dnmt1 , osteosarcoma , apoptosis , cancer research , cancer , cancer cell , chemistry , microbiology and biotechnology , medicine , biology , dna methylation , biochemistry , gene , gene expression

Isovitexin (apigenin-6-C-glucoside, ISOV) is a natural flavonoid that exhibits tumor suppressive activity on various types of cancer. However, it is unknown whether the mechanism of its action in osteosarcoma (OS) is associated with epigenetic regulation and whether it involves DNA methyltransferase 1 (DNMT1), microRNAs and their targets.

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