Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1 | Zendy

Zhifeng Chen | Zendy; Qian Tao | Zendy; Bin Qiao | Zendy; Leitao Zhang | Zendy

Open Access

<p>Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1</p>

Author(s) -

Zhifeng Chen,

Qian Tao,

Bin Qiao,

Leitao Zhang

Publication year - 2019

Publication title -

cancer management and research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.024

H-Index - 40

ISSN - 1179-1322

DOI - 10.2147/cmar.s197583

Subject(s) - gene silencing , microrna , basal cell , cancer research , microbiology and biotechnology , medicine , biology , chemistry , andrology , gene , genetics

Oral squamous cell carcinoma (OSCC), one of the most common cancers worldwide with a high mortality rate, is accompanied by poor prognosis, highlighting the significance of early diagnosis and effective treatment. Long non-coding RNAs (lncRNAs) have been linked with the development and progression of various cancers. In this study, aberrantly expressed lncRNA LINC01116, microRNA-136 (miR-136), and fibronectin1 (FN1) were identified in OSCC using a microarray analysis. Therefore, this study aimed to investigate the role of LINC01116/miR-136/FN1 regulatory axis in OSCC.

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