Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo | Zendy

Lin Peng | Zendy; Yiteng Huang | Zendy; Jian Chen | Zendy; Yi-Xuan Zhuang | Zendy; Fan Zhang | Zendy; Jiongyu Chen | Zendy; Zhou Li | Zendy; Donghong Zhang | Zendy

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Osthole sensitizes with radiotherapy to suppress tumorigenesis of human nasopharyngeal carcinoma in vitro and in vivo

Author(s) -

Lin Peng,

Yiteng Huang,

Jian Chen,

Yi-Xuan Zhuang,

Fan Zhang,

Jiongyu Chen,

Zhou Li,

Donghong Zhang

Publication year - 2018

Publication title -

cancer management and research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.024

H-Index - 40

ISSN - 1179-1322

DOI - 10.2147/cmar.s182798

Subject(s) - nasopharyngeal carcinoma , radiation therapy , cancer research , in vivo , apoptosis , radioresistance , carcinogenesis , medicine , viability assay , annexin , cell growth , mtt assay , pathology , cancer , biology , staining , microbiology and biotechnology , biochemistry , genetics

Radiotherapy is one of the most comment and useful treatment for nasopharyngeal carcinoma (NPC), but the radioresistance remains a major obstacle. Osthole, a natural coumarin derivative, has been shown to have anti-tumor and anti-inflammatory activity. However, the relationship between osthole and NPC treatment, especially for radiotherapy, is still elusive.

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