Long-term tolerability of topical diclofenac sodium 1% gel for osteoarthritis in seniors and patients with comorbidities | Zendy

John H. Peniston | Zendy; Gold | Zendy; Wieman | Zendy; Alwine | Zendy

Open Access

Long-term tolerability of topical diclofenac sodium 1% gel for osteoarthritis in seniors and patients with comorbidities

Author(s) -

John H. Peniston,

Gold,

Wieman,

Alwine

Publication year - 2012

Publication title -

clinical interventions in aging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.184

H-Index - 76

eISSN - 1178-1998

pISSN - 1176-9092

DOI - 10.2147/cia.s35416

Subject(s) - medicine , tolerability , adverse effect , osteoarthritis , diabetes mellitus , diclofenac , post hoc analysis , diclofenac sodium , population , anesthesia , pharmacology , endocrinology , alternative medicine , environmental health , pathology

Adverse events associated with nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat knee and hand osteoarthritis may be more frequent in certain patient populations. Topical NSAIDs, such as diclofenac sodium 1% gel (DSG), have equivalent efficacy and fewer adverse events compared with oral NSAIDs. This post hoc analysis assessed the long-term tolerability of DSG in elderly patients and patients with an elevated risk of gastrointestinal, cardiovascular, and renal adverse events.

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